Tony Keaveny

Chancellor’s Professor of Mechanical Engineering and Bioengineering
Keywords: mechanics, materials
Research Areas: bioengineering, biomechanics of bone, orthopaedic biomechanics, tissue engineering of bone, mechanical behavior of bone and collagen, bone biology,osteoporosis, finite element modeling, biomechanical testing
Website: http://www.me.berkeley.edu/faculty/keaveny/

Research Description:

The Berkeley Orthopaedic Biomechanics Laboratory, in the Department of Mechanical Engineering at UC Berkeley, was established in 1993 with three broad goals: 1) to educate students in performing independent, high-quality research in orthopaedic biomechanics; 2) to apply the principles of engineering mechanics to understand basic biological processes and mechanisms related to the structure and function of bone; and 3) to apply the principles of mechanical engineering to the design, analysis, and development of bone-prosthetic systems. Congruent with our emphasis on collaboration, our laboratory is closely associated with the medical school at UCSF (particularly the Department of Orthopaedic Surgery) with which we have a number of ongoing joint projects. This collaboration provides input from surgeons, radiologists, biologists and other bioengineers, and provides our students with first-hand experience in various clinical aspects of biomechanics.

Selected Publications:

Eswaran SK, Gupta A, and Keaveny TM. Locations of bone tissue at high risk of initial failure during compressive loading of the human vertebral body. Bone, 41(4): 733-9, 2007.

Eswaran SK, Allen MR, Burr DB and Keaveny TM. A computational assessment of the independent contribution of changes in canine trabecular bone volume fraction and microarchitecture to increased bone strength with suppression of bone turnover. Journal of Biomechanics, 40(15): 3424-31, 2007.

Eswaran SK, Bayraktar HH, Adams MF, Gupta A, Hoffmann PF, Lee DC, Papadopoulos P, and Keaveny TM. The micro-mechanics of cortical shell removal in the human vertebral body. Computer Methods in Applied Mechanics and Engineering, 196: 3025- 3032, 2007.

Bartel DL, Davy DT, and Keaveny TM. Orthopaedic Biomechanics: Mechanics and Design in Musculoskeletal Systems. Pearson Prentice Hall, New Jersey, 2006.

Eswaran SK, Gupta A, Adams MF, Keaveny TM. Cortical and trabecular load sharing in the human vertebral body. Journal of Bone and Mineral Research, 21:307-314, 2006.

Gupta A, Bayraktar HH, Keaveny TM and Papadopoulos P. Constitutive and numerical implementation of a plasticity model for trabecular bone continua. Computational Mechanics, In Press.

Liu S, Sajda P, Saha PK, Wehrli FW, Bevill G, Keaveny TM, and Guo XE. Complete volumetric decomposition of individual trabecular plates and rods and its morphological correlations with anisotropic elastic moduli in human trabecular bone x. Journal of Bone and Mineral Research, 23(2): 223-35, 2008.

Bigley, R.F., Singh, M., Hernandez, C.J., Kazakia, G.J., Martin, R.B., and Keaveny, T.M. Validity of serial milling-based imaging system for microdamage quantification. Bone, 42(1):212-5, 2007

Melton LJ, Riggs BL, Keaveny TM, Achenbach SJ, Hoffmann PF, Camp JJ, Rouleau PA, Bouxsein ML, Amin S, Atkinson EJ, Robb RA, and Khosla S. Structural determinants of vertebral fracture risk. Journal of Bone and Mineral Research, 22(12): 1885-92, 2007.

Bevill G, Easley SK, and Keaveny TM. Side-artifact errors in yield strength and elastic modulus for human trabecular bone and their dependence on bone volume fraction and anatomic site. Journal of Biomechanics, 40(15): 3381-8, 2007.